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Monday, September 24, 2007 Registration
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| 6:00 PM |
Registration - The Inn on Lake Superior (Northern Lights Room) |
| 7:00 PM |
Social - The Inn on Lake Superior (Northern Lights Room) |
Tuesday, September 25 - Northern Lights 2 Room
Chemical Categories and Predictive Toxicology
|
| 9:00 AM |
Welcome
Vince Magnuson, Vice Chancellor, UMD |
| 9:10 AM |
Strategic Testing in REACH - A Testing Paradigm Shift
Kees van Leeuwen, TNO Quality of Life |
| 9:50 AM |
New Approaches in Hazard Identification
Peter Robinson, Environment Canada |
| 10:15 AM |
Categories, QSAR and Hazard Identification
Gilman Veith, International QSAR Foundation |
| 10:30 AM |
Coffee Break |
10:45 AM |
U.S. EPA Experiences Using Category Approaches
Tala Henry, U.S. EPA, OPPT |
| 11:30 AM |
OECD Toolbox for Forming Mechanistic Categories
Ovanes Mekenyan, LMC-Bourgas University |
| 12:00 AM |
Predicting Estrogen Receptor Binding within Categories
Rick Kolanczyk, U.S. EPA MED-Duluth |
| 12:30 AM |
Lunch (catered) |
New Reference Points for Hazard Identification
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| 1:30 PM |
Selective, Nonspecific and Receptor-Based Toxicity
Terry Schultz, The University of Tennessee |
| 2:15 PM |
Narcosis as a Nonspecific Reference for Identifying Hazards
Gilman Veith, International QSAR Foundation |
| 2:45 PM |
Solubility and Fugacity as Toxicity Baselines
Don Mackay, Trent University |
| 3:15 PM |
Coffee Break |
| 3:45 PM |
Dose-Response for Neurological Effects of Narcotics
Philip Bushnell, U.S. EPA (NHEERL) |
| 4:15 PM |
Dose-Response for Reproductive Effects of ER Binders
Pat Schmieder, U.S. EPA MED-Duluth |
| 5:15 PM |
Adjourn |
| 6:30 PM |
Dinner at the Great Lakes Aquarium (catered) |
Wednesday, September 26 - Eagle Harbor Room
Using Systems Approaches to Strategic Testing
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| 9:00 AM |
Toxicity Pathways as an Organizing Concept
Group Discussion |
| 10:15 AM |
Coffee Break |
| 10:45 AM |
Overview of System Biology and Mechanisms
Rory Conolly, U.S. EPA/NCCT |
| 11:15 AM |
Protein Structure in Molecular Systems Biology
David Sheehan, Dept. Biochemistry, University College Cork |
| 12:00 AM |
Lunch |
Systems Approaches (continued)
|
| 1:00 PM |
Bioinformatics for Large "omic" Databases
Imran Shah, U.S. EPA/NCCT |
| 1:30 PM |
Systems Biology in Small Fish Models
Dan Villeneuve, U.S. EPA MED-Duluth |
| 2:15 PM |
System Biology in Amphibian Models
John Nichols, U.S. EPA MED-Duluth |
| 3:00 PM |
Coffee Break |
| 3:30 PM |
Bridging from Individuals to Populations
Matt Etterson, U.S. EPA MED-Duluth |
| 4:15 PM |
Opportunities for Strategic Planning using Systems Models
Gary Ankley, U.S. EPA MED-Duluth |
| 5:00 PM |
Adjourn |
| 7:00 PM |
Dinner in Small Groups |
|
Thursday, September 27- Eagle Harbor Room
Discussions on Potency, Hazard and Classification
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| 9:00 AM |
Classification of Chemicals by Fugacity-Normalized Toxicity
Jon Arnot, Trent University |
| 9:30 AM |
Hazard Identification using Acute/Chronic Effects Ratios
Terry Schultz, The University of Tennessee |
| 9:50 AM |
Predicting Hazards from Extended Fragments
Al Leo, BioByte Corporation |
| 10:15 AM |
Coffee Break |
| 10:45 AM |
Defining Reproductive or Neurological Hazards
Pat Schmieder/Phil Bushnell, U.S. EPA |
| 11:15 AM |
Summary and Next Steps
Gilman Veith, International QSAR Foundation |
| 12:00 AM |
Adjourn - Lunch in Small Groups and Head to the Airport |
Special QSAR Toolbox Training Session
|
| 1:00 PM |
Installing Toolbox on Trainee Laptops - Laboratory of Mathematical Chemistry
Please check recommended system requirements for the installation here |
| 2:00 PM |
Training Session for QSAR Application Toolbox
Ovanes Mekenyan
- Work-Flow Patterns in the Toolbox
- Creating knowledge-based categories
- Interfacing with proprietary databases
|
| 5:00 PM |
Adjourn |
|
Friday, September 28 - Eagle Harbor Room
QSAR Toolbox Training Session (continued)
|
| 9:00 AM |
Training Session for QSAR (continued)
Ovanes Mekenyan
- Identifying analogues categorization tools
- Using interaction mechanism and metabolism for grouping chemicals
|
12:00 AM |
Lunch (catered) |
| 1:00 PM |
Training Session for QSAR Application Toolbox
Ovanes Mekenyan
- Applying data gap filling methods - read-across, trend analysis and QSAR
- Mechanistic applicability domains
- Practice and Tutoring
|
| 5:00 PM |
Adjourn |