Strategic Design of Alternative Methods to Reduce Animal Testing

This project with the University of Tennessee and Utah State University seeks to develop systematic data sets on the reactivity of chemicals to a series of model nucleophiles.  The thiol center in glutathione, the amino center in lysine or butylamine, and the oxygen and ring nitrogen atoms in 2-pyridone are the current model nucleophiles being evaluated.

The International QSAR Foundation serves as a facilitator for a consortium on refining models of skin sensitisation. ExxonMobil, Unilever, Procter & Gamble, RIFM, and the Danish Institute for Toxicology and Risk Assessment are working together to refine the TIMES-SS model developed by the Laboratory of Mathematical Chemistry, Bourgas, Bulgaria, within the next two years. For additional information, please download The Consortium for Skin-Sensitisation.doc