Strategic Design of Alternative Methods to Reduce Animal Testing

The 1st Knoxville workshop in 2005 accomplished a major IQF goal by formulating a conceptual framework for predicting reactive toxicity. At the heart of the conceptual framework is the use of model compounds which simulate natural proteins and other important cellular targets for reactive chemicals and produce a reactivity profile. These model compounds are easily synthesized and react with chemicals in a test tube, so measuring chemical reactivity does not have to involve any animals or cells.

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