Strategic Design of Alternative Methods to Reduce Animal Testing

Monday May 22
19h00 Group Dinner - Hamiltons Steak & Seafood, 2427 North Main – shuttle departs from hotel at 18h30

Tuesday March 23
08h30 Welcome & Introductions - Bill Doucette
08h45 Review of Purpose and Agenda - Gil Veith
09h00 Reactive Toxicity: Progress Report on Filling the Gap - Gil Veith
10h30 Coffee
10h45 GSH Reactivity: an in chemico method and overview of its database - Terry Schultz
11h30 Model improvement in the Skin Sensitization Consortium - Mike Comber

12h15 Catered Lunch
13h00 Current status of reactivity models in aquatic toxicity – Mark Cronin
13h45 Current status of reactivity models in inhalation toxicity – Kendall Wallace
14h30 Estimating reactivity from structure using the OECD (Q)SAR Application Toolbox – Terry Schultz

15h15 Break
15h30 Molecular mechanisms of hepatocyte cytotoxicity and reactivity of α,β- unsaturated carbonyls , quinones versus alkanals - Peter O’Brien
16h15 Charge to the group for selecting model nucleophiles – Gil Veith
19h00 Group Dinner - Le Nonne Ristorante - 129 North 100 East - – shuttle departs from hotel at 18h30

Wednesday March 24
08h45 Summary of Day 1- Gil Veith
09h00 Utilization of cysteine and lysine peptides for screening reactivity of skin sensitizers - Frank Gerberick
09h45 Cysteine vs lysine reactivity: a biological significance - Jean-Pierre Lepoittevin
10h30 Coffee

10h45 Reactions of aldehydes with proteins and cellular targets. - Jon Doorn
11h30 Opportunities for measuring amine reactivity under LINK – Mark Cronin
12h00 Catered Lunch
Transportation to airport as needed

13h00 2-Pyridone as a model for hard nucleophile reactivity - Gil Veith
13h30 Analytical Capabilities of Utah State University – Bill Doucette
14h00 Gaps in Current Models and Correlations - Group Discussion
15h00 Refreshments

15h30 Discussion of Next Steps in Database Development
Dinner on your own (keep receipts)

Thursday March 25
09h00 The Thursday morning session will prepare a summary of the discussions, is open to all interested participants, but not intended to delay your flights home. Participants with possible afternoon connections may leave Wednesday as needed. Those with morning flights will have Thursday airport transportation as needed.
12h00 Adjourn