QSAR has been part of scientific research for more than 50 years, but the power of this QSAR to make safety assessment for chemicals more efficient has only come to light with modern computers. Today, there are many kinds of animal tests needed to judge the safety of chemicals, and QSAR models can already virtually eliminate the need for a number of commonly used screening tests. Reducing animal testing can be achieved by expanding QSAR screening methods for all kinds of animal testing, a goal which can be achieved in the next decade with your help. The incentives to support QSAR research in governments are small because the first priority of regulatory agencies is to protect public health and the environment. As long as animal testing is paid for by industry and satisfies that priority, there is no compelling reason to find better approaches. The incentives to support QSAR by industry are small because established regulatory processes have less uncertainty from a business perspective. Also, since only a few percent of chemicals are now reviewed, some businesses fear that QSAR may give regulators opportunities to screen tens-of-thousands of chemicals which would otherwise not be reviewed. Consequently, the incentive for improving the safety assessment processes for chemicals must come from a public who wants both government and industry to find a better approach that does not require such extensive use of animal testing. The International QSAR Foundation, along with its sponsors and research partnerships, brings QSAR technology into the drive to reduce the reliance on animal testing in safety assessments.