The computerized video games on the market today would have been considered impossible by inventors several decades ago because simulating realistic human activities was far more complex than computers could handle back then. For some years now, realistic flying experience for pilots is gained by flying "virtual" airplane simulators where the science of flight is captured well enough to mimic actual flying under many conditions. Similarly, QSAR consists of computer simulations for animal tests which capture the science of toxicology enough to mimic the results of reference animal tests without using animal exposures. Many QSAR methods have already been used by the U.S. EPA for more than a decade. The best hope to reduce animal testing in the future is to support the Foundation's effort to accelerate the development of computer simulators of animal tests.